R : Copyright 2005, The R Foundation for Statistical Computing Version 2.1.1 (2005-06-20), ISBN 3-900051-07-0 R is free software and comes with ABSOLUTELY NO WARRANTY. You are welcome to redistribute it under certain conditions. Type 'license()' or 'licence()' for distribution details. R is a collaborative project with many contributors. Type 'contributors()' for more information and 'citation()' on how to cite R or R packages in publications. Type 'demo()' for some demos, 'help()' for on-line help, or 'help.start()' for a HTML browser interface to help. Type 'q()' to quit R. > ### *
> ### > attach(NULL, name = "CheckExEnv") > assign(".CheckExEnv", as.environment(2), pos = length(search())) # base > ## add some hooks to label plot pages for base and grid graphics > setHook("plot.new", ".newplot.hook") > setHook("persp", ".newplot.hook") > setHook("grid.newpage", ".gridplot.hook") > > assign("cleanEx", + function(env = .GlobalEnv) { + rm(list = ls(envir = env, all.names = TRUE), envir = env) + RNGkind("default", "default") + set.seed(1) + options(warn = 1) + delayedAssign("T", stop("T used instead of TRUE"), + assign.env = .CheckExEnv) + delayedAssign("F", stop("F used instead of FALSE"), + assign.env = .CheckExEnv) + sch <- search() + newitems <- sch[! sch %in% .oldSearch] + for(item in rev(newitems)) + eval(substitute(detach(item), list(item=item))) + missitems <- .oldSearch[! .oldSearch %in% sch] + if(length(missitems)) + warning("items ", paste(missitems, collapse=", "), + " have been removed from the search path") + }, + env = .CheckExEnv) > assign("..nameEx", "__{must remake R-ex/*.R}__", env = .CheckExEnv) # for now > assign("ptime", proc.time(), env = .CheckExEnv) > grDevices::postscript("seqmon-Examples.ps") > assign("par.postscript", graphics::par(no.readonly = TRUE), env = .CheckExEnv) > options(contrasts = c(unordered = "contr.treatment", ordered = "contr.poly")) > options(warn = 1) > library('seqmon') > > assign(".oldSearch", search(), env = .CheckExEnv) > assign(".oldNS", loadedNamespaces(), env = .CheckExEnv) > cleanEx(); ..nameEx <- "seqmon" > > ### * seqmon > > flush(stderr()); flush(stdout()) > > ### Name: seqmon > ### Title: Sequential Monitoring of Clinical Trials > ### Aliases: seqmon > ### Keywords: design > > ### ** Examples > > ##The following gives the probablility of crossing > ##the boundaries for a O'Brien Flemming (1979) lower and upper bound > ##with five looks at the data under the null hypothosis. > z<-2.04 > a<- -z*sqrt(5/(1:5)) > b<- +z*sqrt(5/(1:5)) > t<- 1:5 > int<- 500* array(c(1),5) > seqmon(a,b,t,int) [1] 2.538522e-06 6.297851e-04 4.453088e-03 1.279521e-02 2.500475e-02 [6] 2.538522e-06 6.297851e-04 4.453088e-03 1.279521e-02 2.500475e-02 > ##This gives the probabilities under the alternative hypothesis if the expected value of the mean difference over it's > ##standard error for one group is 1.5 > u<-1.5 > seqmon(a+u*sqrt(1:5),b+u*sqrt(1:5),t,int) [1] 1.100866e-03 1.347988e-01 4.891156e-01 7.709050e-01 9.116717e-01 [6] 6.739596e-10 4.536244e-08 1.243213e-07 1.776088e-07 2.023763e-07 > > > > ### *