Simulation and group sequential monitoring of randomized multi-arm two-stage Phase IIb/III treatment efficacy trials with time-to-event endpoints


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Documentation for package ‘seqDesign’ version 1.0.2

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censTrial Generation of Pre-Unblinded Follow-Up Data-Sets by Applying the Monitoring Outcomes
monitorTrial Group Sequential Monitoring of Simulated Efficacy Trials for the Event of Potential-Harm, Non-Efficacy, and High-Efficacy
rankTrial Ranking and Selection, and Head-to-Head Comparison of Individual and Pooled Treatment Arms
simTrial Simulation of Multi-Arm Randomized Phase IIb/III Efficacy Trials with Time-to-Event Endpoints
VEpowerPP Unconditional Power to Detect Positive Treatment Efficacy in a Per-Protocol Cohort