MultEq-package {MultEq}R Documentation

Equivalence for multiple endpoints

Description

The package provides tests and confidence intervals for comparing two treatments when there is more than one primary response variable (endpoint) given. The step-up procedure of Quan et al. (2001) is both applied for differences and extended to ratios of means of normally distributed data with equal group variances. A related single-step procedure is also available.

Details

Package: MultEq
Type: Package
Version: 2.0
Date: 2008-01-30
License: GPL

multeq.diff
Equivalence tests and related confidence intervals for differences of normal means of multiple endpoints
multeq.rat
Equivalence tests and related confidence intervals for ratios of normal means of multiple endpoints
clinic
Data set of body measurements in a clinical study

Author(s)

Mario Hasler

Maintainer: Mario Hasler <hasler@biostat.uni-hannover.de>

References

Hothorn, L.A. and Hasler, M. (in process): Proof of hazard and proof of safety in toxicological studies using simultaneous confidence intervals for differences and ratios to control; Quan et al. (2001): Assessmant of equivalence on multiple endpoints, Statistics in Medicine 20, 3159-3173

Examples

data(clinic)

comp <- multeq.diff(data=clinic,grp="fact",method="step.up",margin.up=rep(0.6,5),
                    margin.lo=-rep(0.6,5))
summary(comp)

[Package MultEq version 2.0 Index]