Bayesian continuous reassessment method (CRM) designs for Phase I dose-finding trials.


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Documentation for package ‘bcrm’ version 0.4.2

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bcrm-package Bayesian continuous reassessment method (CRM) designs for Phase I dose escalation trials
bcrm Bayesian continuous reassessment method (CRM) designs for Phase I dose escalation trials.
find.x Obtain samples from the maximum tolerated dose (MTD) distribution.
getprior Samples from the specified prior distribution.
plot.bcrm Plot the estimated dose-toxicity curve
plot.bcrm.sim Plot the operating characteristics from the simulated trials
plot.threep3 Plot the operating characteristics from a standard 3+3 trial
Posterior.BRugs Calculate posterior distribution of CRM model parameter(s)
Posterior.exact Calculate posterior distribution of CRM model parameter(s)
Posterior.R2WinBUGS Calculate posterior distribution of CRM model parameter(s)
print.bcrm Print information regarding a trial conducted using the Bayesian continuous reassessment method
print.bcrm.sim Print information regarding a trial conducted using the Bayesian continuous reassessment method
print.threep3 Print information regarding the operating characteristics of a standard 3+3 design
threep3 Calculate all possible trial pathways for the standard 3+3 design, together with their probability of occurring