Evaluation of surrogate endpoints in clinical trials

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Documentation for package ‘Surrogate’ version 0.1-0

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ARMD Data of the Age-Related Macular Degeneration Study
BifixedContCont Fits a bivariate fixed-effects model to assess surrogacy in the meta-analytic multiple-trial setting (Continuous-continuous case)
BimixedContCont Fits a bivariate mixed-effects model to assess surrogacy in the meta-analytic multiple-trial setting (Continuous-continuous case)
FixedContContIT Fits (univariate) fixed-effect models to assess surrogacy in the continuous-continuous case based on the Information-Theoretic framework
ICA.ContCont Assess surrogacy in the causal-inference single-trial setting (Individual Causal Association, ICA) in the Continuous-continuous case
LongToWide Reshapes a dataset from the 'long' format (i.e., multiple lines per patient) into the 'wide' format (i.e., one line per patient)
MICA.ContCont Assess surrogacy in the causal-inference multiple-trial setting (Meta-analytic Individual Causal Association; MICA) in the continuous-continuous case
MinSurrContCont Examine the plausibility of finding a good surrogate endpoint in the Continuous-continuous case
MixedContContIT Fits (univariate) mixed-effect models to assess surrogacy in the continuous-continuous case based on the Information-Theoretic framework
plot Causal-Inference Plots the (Meta-Analytic) Individual Causal Association
plot Information-Theoretic Provides plots of trial- and individual-level surrogacy in the Information-Theoretic framework
plot Meta-Analytic Provides plots of trial- and individual-level surrogacy in the meta-analytic framework
plot MinSurrContCont Graphically illustrates the theoretical plausibility of finding a good surrogate endpoint in the continuous-continuous case
plot.BifixedContCont Provides plots of trial- and individual-level surrogacy in the meta-analytic framework
plot.BimixedContCont Provides plots of trial- and individual-level surrogacy in the meta-analytic framework
plot.FixedContContIT Provides plots of trial- and individual-level surrogacy in the Information-Theoretic framework
plot.ICA.ContCont Plots the (Meta-Analytic) Individual Causal Association
plot.MICA.ContCont Plots the (Meta-Analytic) Individual Causal Association
plot.MinSurrContCont Graphically illustrates the theoretical plausibility of finding a good surrogate endpoint in the continuous-continuous case
plot.MixedContContIT Provides plots of trial- and individual-level surrogacy in the Information-Theoretic framework
plot.Single.Trial.RE.AA Conducts a surrogacy analysis based on the single-trial meta-analytic framework
plot.UnifixedContCont Provides plots of trial- and individual-level surrogacy in the meta-analytic framework
plot.UnimixedContCont Provides plots of trial- and individual-level surrogacy in the meta-analytic framework
Pos.Def.Matrices Generate 4 by 4 correlation matrices and flag the positive definite ones
Schizo Data of five clinical trials in schizophrenia
Sim.Data.Counterfactuals Simulate a dataset that contains counterfactuals
Sim.Data.MTS Simulates a dataset that can be used to assess surrogacy in the multiple-trial setting
Sim.Data.STS Simulates a dataset that can be used to assess surrogacy in the single-trial setting
Single.Trial.RE.AA Conducts a surrogacy analysis based on the single-trial meta-analytic framework
UnifixedContCont Fits univariate fixed-effect models to assess surrogacy in the meta-analytic multiple-trial setting (continuous-continuous case)
UnimixedContCont Fits univariate mixed-effect models to assess surrogacy in the meta-analytic multiple-trial setting (continuous-continuous case)