War.ss {tdm}R Documentation

Algorithm to estimate individual PK/PD parameters of warfarin with one concentration

Description

Algorithm to estimate individual Pk/PD parameters of warfarin with one concentration at steady-state.

References

Dalere, GM, et al., A graphic for Warfarin Dosage Adjustment, Pharmacotherapy. 1999, 19(4):461-467 ; Theofanus TG, Barile RG. Multiple-dose kinetics of oral anticoagulants: methods of analysis and optimized dosing. J Pharm Sci 1973;62:261-6 ; Bubp J, Coleman R, Mungall D, Raskob G, Hull R. Comparison of warfarin pharmacodynamic model predictions using Manchester comparative reagent vs Simplastin reagent. Clin Pharmacol Ther 1990;47:157.


[Package tdm version 2.1.1 Index]