caBiExp {CalciOMatic}R Documentation

BiExponential Time Course of Intracellular Calcium Concentration

Description

The function caBiExp returns a vector of intracellular calcium concentration ([Ca^2+]) vs time values t. A dCa jump occurs at tOn, followed by a biexponential return to baseline value Ca0. The fast time constant (tau) has a weight fact (between 0 and 1), the slow time constant (tau+dtau) has a weight 1-fact.

Usage

caBiExp(t = 1, tOn = 1, Ca0 = 0.05, dCa = 0.1, tau = 3, fact = 1, dtau = 2)

Arguments

t a vector of time values at which [Ca^2+] is computed (in s)
tOn the time of the [Ca^2+] jump (in s)
Ca0 the baseline [Ca^2+] (in muM)
dCa the [Ca^2+] jump occuring at tOn (in muM)
tau the fast time constant of the [Ca^2+] biexponential return to baseline (in s)
fact the relative weight of the fast time constant of the biexponential decay (a real number between 0 and 1). The relative weight of the slow time constant is given by 1-fact
dtau added to tau, defines the slow time constant of the [Ca^2+] biexponential return to baseline (in s)

Value

A vector containing the [Ca^2+] values. The vector has the two following attributes:

Time a copy of argument t
tOn a copy of argument tOn

Author(s)

Sebastien Joucla sebastien.joucla@parisdescartes.fr

See Also

caMonoExp, caMonoBiExpFromIG

Examples

  ## Simulate a biexponential calcium transient
  Ca <- caBiExp(t    = seq(0,20,0.1),
                tOn  = 2,
                Ca0  = 0.25,
                dCa  = 1,
                tau  = 2,
                fact = 0.7,
                dtau = 8)

  ## Plot the calcium transient vs. time
  plot(attr(Ca,"Time"), Ca, type="l")

  ## Add a vertical dashed line at tOn
  abline(v = attr(Ca,"tOn"), lty = 2)

[Package CalciOMatic version 1.1-3 Index]