caMonoBiExpFromIG {CalciOMatic}R Documentation

Mono- or Bi- Exponential Time Course of Intracellular Calcium Concentration

Description

The caMonoBiExpFromIG function returns a vector of intracellular calcium concentration ([Ca^2+]). A dCa jump occurs at tOn, followed by either a monoexponential or a biexponential return to the baseline value Ca0, depending on the fields of the input list ig. The caMonoBiExpFromIG function is a low-level function of the ratioFitFromCa and directFit functions.

Usage

caMonoBiExpFromIG(t = 1, tOn = 1, ig = NULL)

Arguments

t a vector of time values at which [Ca^2+] is computed (in s)
tOn the time of the [Ca^2+] jump (in s)
ig an object of class "initial_guess", giving the parameters of the decay. This object is a list with the following numerical fields: "log_Ca0", "log_dCa", "log_tau" in the case of a monoexponential decay. In the case of a biexponential decay, the two following fields are also included: "mu" and "log_dtau"

Value

A vector containing the [Ca^2+] values. The vector has the two following attributes:

Time a copy of argument t
tOn a copy of argument tOn

Author(s)

Sebastien Joucla sebastien.joucla@parisdescartes.fr

See Also

caMonoExp, caBiExp

Examples

  ## Parameters of the calcium transient
  Ca0 <- 0.10
  dCa <- 0.25
  tau <- 1

  ## List of initial guesses
  ig_mono <- list(log_Ca0 = log(Ca0),
                  log_dCa = log(dCa),
                  log_tau = log(tau))
  class(ig_mono) <- "initial_guess"

  ## Build the calcium transient
  Ca <- caMonoBiExpFromIG(t   = seq(0,10,0.1),
                          tOn = 2,
                          ig  = ig_mono)

  ## Plot the calcium transient vs. time
  plot(attr(Ca,"Time"), Ca, type="l")

  ## Add a vertical dashed line at tOn
  abline(v = attr(Ca,"tOn"), lty = 2)

[Package CalciOMatic version 1.1-3 Index]