ccl4data {deSolve}R Documentation

Closed chamber study of CCl4 metabolism by rats.

Description

The results of a closed chamber experiment to determine metabolic parameters for CCl4 (carbon tetrachloride) in rats.

Usage

data(ccl4data)

Format

This data frame contains the following columns:

  • time. The time (in hours after starting the experiment)
  • initconc. initial chamber concentration (ppm)
  • animal. This is a repeated measures design; this variable indicates which animal the observation pertains to
  • ChamberConc. chamber concentration at time, in ppm

    Source

    Evans, et al. 1994 Applications of sensitivity analysis to a physiologically based pharmacokinetic model for carbon tetrachloride in rats. Toxicology and Applied Pharmacology 128: 36 – 44.

    Examples

    plot(ChamberConc ~ time,data=ccl4data,xlab="Time (hours)",
             xlim=range(c(0,ccl4data$time)),
             ylab="Chamber Concentration (ppm)",log="y")
    ccl4data.avg<-aggregate(ccl4data$ChamberConc,
                            by=ccl4data[c("time","initconc")],mean)
    points(x ~ time,data=ccl4data.avg,pch=16)                        
             

    [Package deSolve version 1.2-2 Index]