bronch {MCPAN} | R Documentation |
In a long term rodent carcinogenicity study on female B6C3F1 mice, the effect of vinylcyclohexene diepoxide on the incidence of murine alveolar/bronchiolar tumors was assessed. The mice were exposed to 0 mg/ml, (group 0), 25 mg/ml (group 1), 50 mg/ml (group 2), and 100 (group 3) mg/ml, with 50 animals per group.
data(bronch)
A data frame with 200 observations on the following 3 variables.
group
0
1
2
3
, labelling the control and the three dose groupsY
time
Not yet checked for consistency with the source!
Piegorsch WW and Bailer AJ (1997): Statistics for environmental biology and toxicology. Chapman and Hall, London. Table 6.5, page 238.
Portier cJ and Bailer AJ (1989): Testing for increased carcinogenicity using survival-adjusted quantal response tests. Fundamental and Applied Toxicology 12, 731.
data(bronch) # raw tumour counts: table(bronch[c("group","Y")]) # groupwise times of death: boxplot(time ~ group, data=bronch, horizontal=TRUE) # Using poly3estf, we can produce the # summary statistics as presented in # Table 6.6, page 239, of Piegorsch and Bailer (1997): poly3estf(status=bronch$Y, time=bronch$time, f=bronch$group)