logistic {MCPMod}R Documentation

Logistic Model

Description

The model function for the logistic model is defined as

f(d,theta)=E0+Emax/(1 + exp((ED50-d)/delta)).

Usage

logistic(dose, e0, eMax, ed50, delta)

Arguments

dose Dose variable
e0 Left-asymptote parameter, corresponding to a basal effect level (not the placebo effect, though).
eMax Asymptotic maximum change in effect from the basal level.
ed50 Dose giving half of the asymptotic maximum effect.
delta Parameter controlling determining the steepness of the curve.

Details

The logistic model is intended to capture general monotone, sigmoid dose-response relationships.

Value

Response value

References

Pinheiro, J. C., Bretz, F. and Branson, M. (2006). Analysis of dose-response studies - modeling approaches, in N. Ting (ed.). Dose Finding in Drug Development, Springer, New York, pp. 146–171

See Also

betaMod, logistic, sigEmax, linlog, linear, quadratic, exponential


[Package MCPMod version 1.0-2 Index]