hcgi12k {MLDA}R Documentation

DMH dataset for A2780 series sensitive and resistant cell lines

Description

A DMH dataset for A2780 series sensitive and resistant cell lines on HCGI12K array (http://data.microarrays.ca/cpg/). Cell lines include A2780, A2780p3, A2780p5, A2780p6, A2780cp70, MCP1, MCP3, MCP6

Usage

data(hcgi12k)

Format

The format is:

R
A matrix of log-transformed signal intensities for red channel
G
A matrix of log-transformed signal intensities for green channel
Rds
A matrix of log-transformed signal intensities for red channel on dye-swapped array
Gds
A matrix of log-transformed signal intensities for geen channel on dye-swapped array
mito.flag
A vector of flag for mitochondrial features
cl
A vector of class of cell lines. 1 = sensitive cell line 2 = resistant cell line
sample.names
A vector of sample names
flag
A matrix of flag of low quality probes. The low quality probes are flagged as -50, otherwise are flagged as 0
flagds
A matrix of flag of low quality probes on dye-swapped arrays. The low quality probes are flagged as -50, otherwise are flagged as 0

Details

The background of dataset have been corrected, the controls (SA1, SA2, Blank and Arabidopsis) on hcgi12k array have been excluded.

A2780: A human ovarian adenocarcinoma cell line derived from an untreated patient
A2780p3: A clonal derivative of A2780
A2780p5: A clonal derivative of A2780
A2780p6: A clonal derivative of A2780
A2780cp70: A resistant derivative of A2780 isolated after exposure to cisplatin
MCP1, MCP3 and MCP6: In vitro selected resistant derivatives of A2780, isolated after a multiple explosures to increasing cisplatin concentration

Source

http://www.ebi.ac.uk/microarray-as/aer/#ae-browse/q=E-TABM-210[2]

Examples

data(hcgi12k)


[Package MLDA version 1.0-1 Index]