ParaNCA.MIX {bear} | R Documentation |
Noncompartmental analysis (NCA) approach is used to compute AUCs and the terminal elimination rate constants (lambda z) for drug plasma concentration. The linear trapezoidal method is applied to calculate AUC(time 0 to the last measurable Cp). The extrapolated AUC (from time of the last measurable Cp to time infinity) is equal to the last measurable Cp divided by lambda z.
Statistical analysis (lme, 90CI...): With a two-treatment, two-sequence, one-period, parallel design, bear deploys the linear mixed effect model (lme). The statistical model includes a factor regarding only one source of variation - treatment. There are no sources of variation associated with sequence or period because there are no sequences or periods in a parallel design. Moreover, lme in nlme package is used to obtain estimates for the adjusted differences between treatment means and the standard error. Log-transformed BA measures will also be analyzed.