NCAdemo.BANOVA {bear} | R Documentation |
Noncompartmental analysis (NCA) approach is used to compute AUCs and the terminal elimination rate constants (lambda z) for drug plasma concentration. The linear trapezoidal method is applied to calculate AUC(time 0 to the last measurable Cp). The extrapolated AUC (from time of the last measurable Cp to time infinity) is equal to the last measurable Cp divided by lambda z.
Statistical analysis (ANOVA(lm), 90CI...): With a two-treatment, two-period, two-sequence randomized crossover design, ANOVA statistical model includes factors of the following sources: sequence, subjects nested in sequences, period and treatment. ANOVA will be applied to obtain estimates for the adjusted differences between treatment means and the standard error associated with these differences. Log-transformed BA measures will also be analyzed.