ParaTTT.MIX {bear} | R Documentation |
The TTT method is based on the Bateman function. The Bateman function has two outstanding points. First, the maximum of the curve (Cmax at Tmax) and secondly, the inflection point of the curve (Cinpt at Tinpt). The inflection point of the curve describes the point where the algebraic sign of the curvature changes. Tinpt is equal to two times Tmax. Thus, The twofold of the observed Tmax value can be used as a threshold of time points to be included in the calculation of lambda(z).
Statistical analysis (lme, 90CI...): With a two-treatment, two-sequence, one-period, parallel design, bear deploys the linear mixed effect model (lme). The statistical model includes a factor regarding only one source of variation - treatment. There are no sources of variation associated with sequence or period because there are no sequences or periods in a parallel design. Moreover, lme in nlme package is used to obtain estimates for the adjusted differences between treatment means and the standard error. Log-transformed BA measures will also be analyzed.
Scheerans C, Derendorf H and C Kloft. Proposal for a Standardised Identification of the Mono-Exponential Terminal Phase for Orally Administered Drugs. Biopharm Drug Dispos 29, 145-157 (2008).