description_TOST_lnAUC0INF {bear}R Documentation

Description for Two One-Sided Test for lnAUC0INF

Description

Interpretation: Ho: MEAN-test/MEAN-ref =< ln(lower acceptance) or MEAN-test/MEAN-ref >= ln(Upper acceptance) Ha: ln(lower acceptance) < MEAN-test/MEAN-ref < ln(Upper acceptance) If at least one of P value is more than 0.05, we will not reject the null hypothesis (Ho).

References

1. Chow SC and Liu JP. Design and Analysis of Bioavailability- Bioequivalence Studies. 3rd ed., Chapman & Hall/CRC, New York (2009). 2. Schuirmann DJ. On hypothesis testing to determine if the mean of a normal distribution is continued in a known interval.Biometrics, 37, 617(1981). 3. Schuirmann DJ. A comparison of the two one-sided tests procedure and the power approach for assessing the equivalence of average bioavailability. Journal of Pharmacokinetics and Biopharmaceutics, 15, 657-680 (1987). 4. Anderson S and Hauck WW. A new procedure for testing equivalence in comparative bioavailability and other clinical trials. Communications in Statistics-Theory and Methods, 12, 2663-2692 (1983).


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