RepNCA.MIX {bear}R Documentation

NCA and lme for replicated study

Description

Noncompartmental analysis (NCA) approach is used to compute AUCs and the terminal elimination rate constants (lambda z) for drug plasma concentration. The linear trapezoidal method is applied to calculate AUC(time 0 to the last measurable Cp). The extrapolated AUC (from time of the last measurable Cp to time infinity) is equal to the last measurable Cp divided by lambda z.

Statistical analysis (lme, 90CI...): With a two-treatment, more than two period, two-sequence randomized crossover design, linear mixed-effects model may be used. The lme in nlme package is used to obtain estimates for the adjusted differences between treatment means and the standard error associated with these differences. Log-transformed BA measures will also be analyzed.


[Package bear version 2.3.0 Index]