AIC_BANOVA {bear} | R Documentation |
This method selects data points to estimate lambda(z) based on the minimun AIC values. It starts with the last three data points from the concentration -time profile, performing log-linear regression to calculate the slope of that tail portion of the concentration-time curve. And then the last 4 data points, the last 5 data points, on and on until it reaches the data point right after Cmax. Thus, this method will not include the data point of (Tmax, Cmax).
Statistical analysis (ANOVA(lm), 90CI...): With a two-treatment, two-period, two-sequence randomized crossover design, ANOVA statistical model includes factors of the following sources: sequence, subjects nested in sequences, period and treatment. ANOVA will be applied to obtain estimates for the adjusted differences between treatment means and the standard error associated with these differences. Log-transformed BA measures will also be analyzed.