logdata {bear} | R Documentation |
This function will help you to choose appropriate sample size.
R-code based on SAS-code by (1) B. Jones and M.G. Kenward Design and Analysis of Cross-Over Trials Chapman & Hall/CRC, Boca Raton (2nd Edition 2000) (2) S. Patterson and B. Jones Bioequivalence and Statistics in Clinical Pharmacology Chapman & Hall/CRC, Boca Raton (2006) /*** WARNING : PROGRAM OFFERED FOR USE WITHOUT ANY GUARANTEES ***/ /*** NO LIABILITY IS ACCEPTED FOR ANY LOSS RESULTING FROM USE OF ***/ /*** THIS SET OF SAS INTRUCTIONS ***/ Modification of degrees of freedom according to a personal message by D. Hauschke (E-mail 2006-01-05) Tested in R-versions 2.6.2 / 2.5.1 / 1.9.1 / 1.9.0 2008-04-04 Sample size R-code was referred from Helmut Schuetz BEBAC - Consultancy services for Bioequivalence and Bioavailability Studies 1070 Vienna, Austria
Hauschke D, Steinijans VW, Diletti E and Burke M. Sample size determination for bioequivalence assessment using a multiplicative model. J. Pharmacokin. Biopharm. 20:557-561 (1992).