epilepticBC {glmmAK} | R Documentation |
This data set considers information from a clinical trial of 59 epileptics, reported by Thall and Vail (1990). For each patient, the number of epileptic seizures was recorded during a baseline period of eight weeks. Patients were then randomized to treatment with the anti-epileptic drug progabide, or to placebo in addition to standard chemotherapy. The number of seizures was then recorded in four consecutive two-weeks intervals.
This is a transformed version of the original data
(epileptic
) which allows directly to fit models
described in Breslow and Clayton (1993) or in Kleinman and Ibrahim
(1998).
There are 4 rows in the dataset for each of 59 patients.
data(epilepticBC)
A data frame with 236 observations on the following 10 variables.
id
visit
seizure0
age
Seizure
Base
seizure0
. Base
=log(seizure0
/4).Trt
Base.Trt
Base
*Trt
.Age
Age
=log(age
).Visit
visit
. Visit
=(2*visit
-5)/10.Thall, P. F., and Vail, S. C. (1990) Some covariance models for longitudinal count data with overdispersion. Biometrics, 46, 657–671.
Breslow, N. E. and Clayton, D. G. (1993). Approximate inference in generalized linear mixed models. Journal of the American Statistical Association, 88, 9–25.
Kleinman, K. P. and Ibrahim, J. G. (1998). A semi-parametric Bayesian approach to generalized linear mixed models. Statistics in Medicine, 17, 2579–2596.
data(epilepticBC) ## maybe str(epilepticBC); plot(epilepticBC) ...