nsclc {ic50} | R Documentation |
For purpose of computational, lesion-based prediction of compound
activity in 84 non-small cell lung cancer (NSCLC) cell lines, these
were treated with a selection of compounds to measure the respective
concentration where 50 per cent of cell growth was inhibited after a
predefined time period. Most of the screening experiments were
performed on 384 (16 x 24)-well plates, were the experimental setup was
designed according to the arrangement in the files
"mpi384_measure.txt"
, "mpi384_control.txt"
and
"mpi384_dilution.txt"
that are installed together with the
package.
These data sets are the direct output from a signal reader of the 384-well plates for the A549, Calu1, H322 and H2429 cancer cell lines selected from the 84 NSCLC cell lines collection. A tab-delimited version is installed together with the package.
Frommolt P, Thomas RK (2008): Standardized high-throughput evaluation of cell-based compound screens. BMC Bioinformatics, 9(1): 475
Sos ML, Michel K, Zander T, Frommolt P, Weiss J, et al. (2008): Predicting drug activity in non-small cell lung cancer based on genetic lesions. Submitted