sphase {maxstat}R Documentation

S-phase fraction of tumor cells

Description

S-phase fraction of tumor cells in breast cancer patients.

Usage

data(sphase)

Format

This data frame contains the following columns:

SPF
S-phase fraction
RFS
recurrence free survival
cens
censoring indicator (1 event)

Details

The data have been used to address the question whether a simple cutpoint in S-phase fraction can be used to discriminate between patients with good and bad prognosis (for example in Hothorn & Lausen, 2003).

Source

J. Pfisterer, F. Kommoss, W. Sauerbrei, D. Menzel, M. Kiechle, E. Giese, M. Hilgarth & A. Pfleiderer (1995). DNA flow cytometry in node positive breast cancer: Prognostic value and correlation to morphological and clinical factors. Analytical and Quantitative Cytology and Histology 7(6), 406–412.

References

Torsten Hothorn & Berthold Lausen (2003). On the Exact Distribution of Maximally Selected Rank Statistics. Computational Statistics & Data Analysis 43, 121–137.

Examples

data(sphase)
maxstat.test(Surv(RFS, cens) ~ SPF, data=sphase, smethod="LogRank",
pmethod="Lau94")
maxstat.test(Surv(RFS, cens) ~ SPF, data=sphase, smethod="LogRank",
pmethod="Lau94", iscores=TRUE)
maxstat.test(Surv(RFS, cens) ~ SPF, data=sphase, smethod="LogRank",
pmethod="HL")
maxstat.test(Surv(RFS, cens) ~ SPF, data=sphase, smethod="LogRank",
pmethod="condMC", B = 9999)
plot(maxstat.test(Surv(RFS, cens) ~ SPF, data=sphase, smethod="LogRank"))


[Package maxstat version 0.7-12 Index]