mixlow-package {mixlow} | R Documentation |
Uses a mixed-effects model to calculate parameters of concentration- response curves. These parameters are used in calculating Loewe interaction indices to quantify drug synergism/antagonism.
Package: | mixlow |
Type: | Package |
Version: | 1.0 |
Date: | 2008-06-27 |
License: | GPL-2 |
Functions are generally called in this order: readDataFile
,
prepareData
, doNls
, doNlme
, and doLoewe
.
Plot functions are available to view results graphically, and values
returned can be used to create custom plots.
John Boik jcboik@stanford.edu
Boik J.C., Newman R.A., Boik R.J. (2008) Quantifying synergism/antagonism using nonlinear mixed-effects modeling: a simulation study. Statistics in Medicine 27(7), 1040-61
Boik J.C. Narasimhan B. (2008, submitted) "Introducing the R Package mixlow for Assessment of Drug Synergism/Antagonism"
# trayData data object is obtained using the readDataFile function data("trayData") mixlowData <- prepareData(trayData) trays <- getTrays(trayData) parameterDefaults <- getNlsParameterDefaults(trays[1:9]) nlsData = doNls(mixlowData, parameterDefaults) nlmeData = doNlme(mixlowData, nlsData) loeweData = doLoewe(mixlowData, nlmeData)