mixlow-package {mixlow}R Documentation

Calculate synergism/antagonism indices based on concentration- response curve parameters

Description

Uses a mixed-effects model to calculate parameters of concentration- response curves. These parameters are used in calculating Loewe interaction indices to quantify drug synergism/antagonism.

Details

Package: mixlow
Type: Package
Version: 1.0
Date: 2008-06-27
License: GPL-2

Functions are generally called in this order: readDataFile, prepareData, doNls, doNlme, and doLoewe. Plot functions are available to view results graphically, and values returned can be used to create custom plots.

Author(s)

John Boik jcboik@stanford.edu

References

Boik J.C., Newman R.A., Boik R.J. (2008) Quantifying synergism/antagonism using nonlinear mixed-effects modeling: a simulation study. Statistics in Medicine 27(7), 1040-61

Boik J.C. Narasimhan B. (2008, submitted) "Introducing the R Package mixlow for Assessment of Drug Synergism/Antagonism"

Examples

# trayData data object is obtained using the readDataFile function
data("trayData")
mixlowData <- prepareData(trayData)
trays <- getTrays(trayData)
parameterDefaults <- getNlsParameterDefaults(trays[1:9])
nlsData = doNls(mixlowData, parameterDefaults) 
nlmeData = doNlme(mixlowData, nlsData)
loeweData = doLoewe(mixlowData, nlmeData)


[Package mixlow version 0.01.1 Index]