Mutagenicity {mratios} | R Documentation |
Mutagenicity assay for 4 doses of a compound (hydroquinone) against a negative (vehicle) control and a positive (active) control (cyclophosphamide). Hydroquinone was applied in doses of 30, 50, 70, 100 mg/kg, positive control was applied with 25mg/kg. Counts of micronuclei in polychromatic erythrocytes after 24h are taken as a measure for the potency to induce chromosome damage. Data of male mice are presented (Hauschke et al., 2005).
data(Mutagenicity)
A data frame with 31 observations on the following 2 variables.
Treatment
Cyclo25
Hydro100
Hydro30
Hydro50
Hydro75
Vehicle
MN
Adler, ID, and Kliesch, U (1990): Comparison of single and multiple treatment regiments in the mouse bone marrow micronucleus assay for hydroquinone and cyclophosphamide. Mutation Research 234, 115-123.
Hauschke, D, Slacik-Erben, R, Hansen, S, Kaufmann,R (2005): Biostatistical Assessment of mutagenicity studies by including the positive control. Biometrical Journal 47, 82-87.
data(Mutagenicity) str(Mutagenicity) boxplot(MN~Treatment, data=Mutagenicity)