pbc {randomSurvivalForest}R Documentation

Primary Biliary Cirrhosis (PBC) Data

Description

Data from the Mayo Clinic trial in primary biliary cirrhosis (PBC) of the liver conducted between 1974 and 1984. A total of 424 PBC patients, referred to Mayo Clinic during that ten-year interval, met eligibility criteria for the randomized placebo controlled trial of the drug D-penicillamine. The first 312 cases in the data set participated in the randomized trial and contain largely complete data. The additional 112 cases did not participate in the clinical trial, but consented to have basic measurements recorded and to be followed for survival. Six of those cases were lost to follow-up shortly after diagnosis, so the data here are on an additional 106 cases as well as the 312 randomized participants. Missing data items are denoted by NA.

Format

A data frame containing:
days survival time in days
status censoring indicator
drugs 1=D-penicillamine, 2=placebo
age age in days
sex 0=female, 1=male
asictes presence of asictes, 0=no 1=yes
hepatom presence of hepatomegaly, 0=no 1=yes
spiders presence of spiders, 0=no 1=yes
edema presence of edema (0, 0.5, 1)
bili serum bilirubin in mg/dl
chol serum cholesterol in mg/dl
albumin albumin in gm/dl
copper urine copper in ug/day
alk alkaline phosphatase in U/liter
sgot SGOT in U/ml
trig triglicerides in mg/dl
platelet platelets per cubic ml/1000
prothrombin prothrombin time in seconds
stage histologic stage of disease

Source

Flemming and Harrington, 1991, Appendix D.1.

References

Flemming T.R and Harrington D.P., (1991) Counting Processes and Survival Analysis. New York: Wiley.

Examples

data(pbc, package = "randomSurvivalForest")

[Package randomSurvivalForest version 3.5.1 Index]