Clonal Heterogeneity Analysis Tool


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Documentation for package ‘CHAT’ version 1.1

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CHAT-package Clonal Heterogeneity Analysis Tool
A0SD.BAF B-allele frequencies of selected chromosomes for TCGA sample A1-A0SD.
A0SD.LRR Copy number information of selected chromosomes for TCGA sample A1-A0SD.
ApproxBIC Approximate BIC calculation
CHAT Clonal Heterogeneity Analysis Tool
Dist Distance from point to a line
DPfitSamples MCMC fitting of sAGP values
findRobustPeaks Find well-separated peaks
getAGP AGP estimation main function
getAmpDel Fraction of amplification or deletion in the genome
getBAFmean Compute mean of BAF
getCanonicalLines Regression lines on canonical points with same number of minor alleles
getCCF CCF estimation main function
getCoord Computes coordinates of a canonical point
getCosine Computes cosine value of the angle for two vectors.
getDiploidOrigin Estimate diploid origin in higher ploidy samples
getDistToPath Find nearest distance from a data point to a canonical line
getDPfit MCMC fitting for single sample
getGrid Find all the coordinates for canonical points
getHets Obtain germline heterozygous markers
getKmeans K-means clustering of data points
getLOH Fraction of loss-of-heterozygosity
getOrigin Inference of Origin Cluster
getPara Initialize parameters for AGP estimation
getPara.sAGP Initialize parameters for sAGP estimation.
getPeaks Find peaks on a curve
getPermutation Null distribution for estimated AGP.
getPloidy Genomewide average ploidy
getsAGP Segment-specific AGP estimation main function
getSampleAGP AGP inference by sample
getSampleCCF CCF estimation by sample.
getSeg Perform DNA segmentation and calculate folded BAF and logR ratios.
getSegChr Perform binned DNA segmentation by chromosome
getSegChr.CBS Perform circular binary segmentation by chromosome
getSegPurity Segment-specific AGP inference by sample
getSumDist Compute the summation of distances
getUnifiedMap Merge adjacent break points
is.nearCP Near canonical position
mcmc MCMC parameters.
MergeBreakPointsByChr Merge break points from two sets
NormalizeLRR Normalize LRR values
plotBAFLRR BAF-LRR plot
plotIdentifiableZone Plot Identifiable Zone on sAGP-SAF plot
prior Prior parameters for MCMC
SampleNMM Normal-Uniform mixture model fitting