AUC {PK}R Documentation

Area Under the Concentration Time Curve

Description

Estimation of area under the concentration time curve (AUC) and area under the first moment curve (AUMC).

Usage

AUC(conc, time, exact=NA, numintp=2, numtail=3, prev=0)  

Arguments

conc levels of concentrations.
time time points of concentration assessment.
exact time point for linear interpolation/extrapolation.
numintp number of last data points used for linear interpolation/extrapolation.
numtail number of last data points used for tail area correction.
prev pre-dosing value.

Details

Estimation of the observed area under the concentration time curve (AUC 0-tlast) and observed area under the first moment curve (AUMC 0-tlast) using the linear trapezoidal method.

Estimation of the linearly interpolated area under the concentration time curve (AUC 0-exact) and linearly interpolated area under the moment curve (AUMC 0-exact). The time point for linear interpolation/extrapolation must be after the last but one time point of concentration assessments.

Estimation of the total area under the concentration curve (AUC 0-infinity) and total area under the first moment curve (AUMC 0-infinity) by using a tail area correction similar as suggested by Perrier and Gibaldi (Appendix D, 1982).

If the pre-dosing value indicating that the intrinsic level is greater than 0, the pre-dosing value is subtracted from all concentration levels before calculation of AUC and AUMC.

Value

Data frame including AUC and AUMC estimates.

Note

Records including missing values and values below zero are omitted.

Author(s)

Martin J. Wolfsegger and Thomas Jaki

References

Cawello W. (2003). Parameters for Compartment-free Pharmacokinetics. Standardisation of Study Design, Data Analysis and Reporting. Shaker Verlag, Aachen.

Gibaldi M. and Perrier D. (1982). Pharmacokinetics. 2nd Edition. Marcel Dekker, New York and Basel.

Examples

## example from Cawello W. (2003, page 70 and 74)
time <- c(0, 0.25, 0.5, 0.75, 1, 1.5, 2, 2.5, 3, 4, 5, 6)
conc <- c(0, 5.67, 20.6, 28.7, 22.5, 17.4, 17.7, 13.4, 11.0, 8.23, 5.14, 2.84) 
AUC(conc=conc, time=time, exact=7, numtail=4)

[Package PK version 0.04 Index]