DS.gamma {BayesQTLBIC}R Documentation

Darvasi and Soller correction factor gamma

Description

Calculate Darvasi and Soller correction factor gamma for QTL mapping in selectively genotyped populations

Usage

DS.gamma(p)

Arguments

p proportion sampled (p/2 per sampled tail)

Details

For a given number of individuals genotyped, power of detection of QTL for a continuous trait (assumed normally distributed) is increased if individuals are sampled from the tails of the phenotypic distribution. For small gene effects, if proportion p/2 is sampled from each tail of the phenotypic distribution, naive estimates of marker effects are inflated by the factor gamma_p (to first order in the size of gene effects) where:

gamma_p = 1 + qnorm((1 - p/2)*dnorm(qnorm(p/2))/(p/2))

Value

the value of gamma_p

Author(s)

Rod Ball (rod.ball@AT@scionresearch.com)

References

Darvasi, A. and Soller, M. 1992: Selective genotyping for determination of linkage between a locus and a quantitative trait locus. Theoretical and Applied Genetics 85: 353–359.

Examples

DS.gamma(p = c(0.05,0.1,0.25))

[Package BayesQTLBIC version 1.0-0 Index]