sonecpmt {PKtools}R Documentation

sonecpmt

Description

A function for a one compartment model with first order absorption with a sqrt transformation.

Usage

sonecpmt(dose,time,lVol,lKa, lCl)

Arguments

dose numeric representation of the dose
time a vector of the time measurements
lVol the numeric parameter log of volume of distribution
lKa the numeric parameter log of absorption
lCl the numeric parameter log of clearance

Value

The value of the expression sqrt(dose * exp(lKa) * (exp(-(exp(lCl)/exp(lVol)) * time) - exp(-exp(lKa) * time))/(exp(lVol) * (exp(lKa) - (exp(lCl)/exp(lVol)))))

Author(s)

M.S. Blanchard<sblanchard.coh.org

See Also

RunNM

Examples

library(nlme) 
data(Theoph) 
Theoph=Theoph[Theoph$Subject==2 & Theoph$Time>0,]
dose=Theoph$Dose
time=Theoph$Time
exp.sconc=sonecpmt(dose,time,lVol=-.8, lKa=.3, lCl=-3.2)
exp.sconc

[Package PKtools version 1.5-0 Index]