lonecpmt {PKtools}R Documentation

lonecpmt

Description

A function for a one compartment model with first order absorption with a natural log transformation.

Usage

lonecpmt(dose,time,lVol,lKa, lCl)

Arguments

dose numeric representation of the dose
time a vector of the time measurements
lVol the numeric parameter log of volume of distribution
lKa the numeric parameter log of absorption
lCl the numeric parameter log of clearance

Value

The value of the expression log(dose * exp(lKa) * (exp(-(exp(lCl)/exp(lVol)) * time) - exp(-exp(lKa) * time))/(exp(lVol) * (exp(lKa) - (exp(lCl)/exp(lVol)))))

Author(s)

M.S. Blanchard<sblanchard.coh.org

See Also

RunNM

Examples

library(nlme) 
data(Theoph) 
Theoph=Theoph[Theoph$Subject==2 & Theoph$Time>0,]
dose=Theoph$Dose
time=Theoph$Time
exp.lconc=lonecpmt(dose,time,lVol=-.6, lKa=.3, lCl=-3)
exp.lconc

[Package PKtools version 1.5-0 Index]