NCA Calculation and Population PK Model Diagnosis


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Documentation for package ‘ncappc’ version 0.2.1.1

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calc.stat Calculates a set of statistics for a given array of numbers.
dv.plot Plots drug plasma concentration vs time data
est.nca Estimates individual NCA metrics from concentration vs time data. data.
histobs.plot Plots histogram of selected set of NCA metrics.
histpop.plot Plots population histogram of the NCA metrics selected for model diagnosis.
nca.deviation.plot Plot individual deviation of NCA metrics estimated from observed and simulated data
nca.npde Calculates individual normalized prediction distribution errors (NPDE) from PDE data.
nca.npde.plot Plots population histogram of the NCA metrics selected for model diagnosis.
nca.pde.deviation.outlier Calculates individual prediction distribution errors (PDE) and scaled deviation of NCA metrics estimated from observed and simulated data. Identifies outlier to population PK model.
ncappc Performs NCA calculations and population PK model diagnosis.
read_nm_table Read nonmem table files produced.